The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
نویسندگان
چکیده
منابع مشابه
Plasma concentrations of methimazole, a metabolite of carbimazole, in hyperthyroid patients.
1 Carbimazole was administered to nine hyperthyroid patients, and blood samples were taken at various time intervals for analysis of carbimazole, and its metabolite methimazole.2 A technique was developed for the measurement of methimazole in serum using a High-Pressure Liquid Chromatograph, which could detect nanogram quantities of this metabolite.3 After a single oral dose, the patients' bloo...
متن کاملPropylthiouracil, and methimazole, and carbimazole-related hepatotoxicity.
INTRODUCTION Propylthiouracil (PTU) has been used for the treatment of hyperthyroidism since the 1940s, but over the years reports of significant hepatotoxicity have come forth, particularly in children. This led to a black box warning being issued by the US FDA in 2009, followed by a similar warning by the European Medicines Agency and the United Kingdom Medicines and Healthcare Regulatory Age...
متن کاملHepatotoxicity in hyperthyroid patient after consecutive methimazole and propylthiouracil therapies
Methimazole (MMI) and propylthiouracil (PTU) are widely used antithyroid drugs (ATD) that have been approved for the treatment of hyperthyroidism. Hepatotoxicity may be induced by these drugs, though they exert dissimilar incidence rates of hepatotoxicity and, possibly, with different underlying pathogenic mechanisms. We report the case of a 55-year-old woman with no relevant medical history di...
متن کاملTeratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil.
Thyrotoxicosis occurs in about 0.2% of pregnancies and is caused most frequently by Graves disease (Burrow, ’85; Kriplani et al., ’94). Graves disease is an autoimmune disorder characterized by the production of antibodies, immunoglobulins of the IgG class, directed against thyroid stimulating hormone (TSH) receptors (Shoenfeld and Schwartz, ’84). This results in the excess production of thyroi...
متن کاملthe effect of methimazole on thyroid gland uptake of technetium in hyperthyroid patients
introduction: the aim of this study was to investigate the effect of methimazole on technetium-99m reabsorbing by thyroid gland , it may be possible to perform thyroid scan when the patients are on the methimazole, this can be time saving and decrease the adverse effects of discontinuing methimazole. patients and methods: among all the patients with hyperthyroidism who referred to nuclear medic...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1980
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1980.tb05823.x